解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科，口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学，全科和内科
医学，法律
医学，研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学，核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学，临床
abstract：:Cytosolic liver glutathione S-transferase (GST) activity was decreased for CDNB and DCNB as substrates in long term alloxan induced diabetes. Similar to cytosolic, microsomal glutathione S-transferase activity was also decreased for CDNB. In contrast, both microsomal and cytosolic GST activities for ETA as well as cyt...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:No strains resistant to all tested antibiotics were found among the 33 Gram-positive and 17 Gram-negative bacteria isolated from non-parenteral drugs and purified water. Three strains: S. aureus, coagulase-negative staphylococcus and B. cereus have been found to be resistant to 6-8 antibiotics, whereas six Gram-negati...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The toxicity of "Polfa" perphenazine and its profile of pharmacological properties were estimated. LD50 values calculated in rats were 2000 mg/kg and 325 mg/kg, after p.o. and i.p. administration respectively. Chronic toxicity of the perphenazine was evaluated during the period of 3 month of the drug treatment p.o. or...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The effects of chronic oral administration of propanolol and metoprolol on blood pressure and GABAergic function were investigated in spontaneously hypertensive rats (SHR) and compared with the effect of dihydralazine. Under the experiment conditions employed all drugs reduced significantly (p < 0.01) arterial pressur...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Some new derivatives of 5-alkylaminomethyl-3-benzoyl-7-oxo-6,7-dihydroisoxazolo[4,3- d]pyrimidine [II-VI] and 7-amine substituted 3-benzoyl-5-phenylisoxazolo[4,3-d]pyrimidine [VIII-X] were synthesized. Preliminary results of pharmacological screening of compounds synthesized as [II-V,IX,X] have been presented. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Five new dipeptides containing epsilon-aminocaproic acid were synthesized. All dipeptides markedly inhibit fibrinolytic activity of plasmin but only in low concentration (0.0002M). In higher concentration fibrinolytic activity was observed. Activity of dipeptides containing epsilon-aminocaproic acid, which antifibrino...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:For the evaluation of the potential carcinogenic properties of TPP the Syrian hamster embryo cell transformation test was employed. TPP did not induce morphological cell transformation in these cells. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The studies of separated and isolated components of Lipotropin-Polfa preparation by determining the contents of nitrogen and qualitative and quantitative composition of amino acids were performed. The component I which constituted 85% of the preparation weight, molecular weight ca. 3500, was separated by means of elec...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Tree methods of synthesis of 2-(2-[2-(3,4,5-trimethoxybenzamido)ethylthio] benzenesulphonyl)guanidines (IVa-b, Va-XIVa, VIII-XII) are described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of compound [IVb, VIa, XIa-XIVa] and substrates [IIIc-f] ar...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Investigations of some immune parameters were carried out in healthy humans receiving TPP in doses of 50, 100, 300 and 600 mg daily for 14 days. The percent and composition of T lymphocyte subsets were studied along with the ability to generate interleukin-1 (Il-1) and interleukin-2 (Il-2) as well as spontaneous and P...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:2-Methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one (III) was reacted with amines IVa-j to give corresponding 2-methyl-3H-pyrido[2,3-d]pyrimidin-4-ones (Va-j) substituted at position 3. These reactions afforded non-cyclic by-products VIa', VIg', and VIh' which were converted into compounds Va, Vg and Vh by the action of POCl3....
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The preliminary studies on acidic degradation of heparin were performed. The UV-VIS and 1H-NMR techniques were used. The analogical features of degradation products of heparin, glucuronic acid and furfural were found (7 characteristic groups). ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The synthesis of pyrazine derivatives, e.g. 1,3,4-thiodiazole (I, III-V, XII), 1,2,4-triazole (II) and N-substituted amidrazones is reported. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Qualitative and quantitative content of aromatic acids in callus tissues, cells in suspension cultures and intact plants of Penstemon serrulatus was determined by paper and gas chromatography. It has been observed that these acids occur in the investigated material mainly in bounded form. The largest quantities of phe...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The synthesis of fluorostyryl derivatives of 3H-pyrido[2,3]pyrimidine-4-one was described. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The research concerned the influence of the liposomally-entrapped indomethacin on its absorption after intragastric administration to rats. It was found that the indomethacin entrapped in liposomes has a favorable influence on the bioavailability in comparison to sole indomethacin suspension. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Reactions of methyl phthalimidodithiocarbamate with secondary amines were described. S-methyl and S-methylenecarboethoxy derivatives news compound were obtained. The reactions S-methyl derivatives with morpholine, piperidine and pyrrolidine were investigated. ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The rate of HCl neutralization by dihydroxyaluminum sodium carbonate (DHASC), hydrotalcite (HT) and dihydroxyaluminum aminoacetate (DHAAA) in the presence of different amount of pepsin (PP) has been studied at constant pH = 3.0. The results can be explained using Weibull distribution function by comparing the kinetica...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Concentration of ibuprofen in rabbit blood was found to be considerably higher after application of Imbun-500 suppositories, containing 500 mg of ibuprofen lysine salt equivalent to 292.6 mg of free ibuprofen, than after application of ibuprofen dragees containing 400 mg of the free drug. Parameters characterizing bio...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A method for the coulometric determination of primaquine is presented. The coulometric titration is carried out in the anode compartment, in the supporting electrolyte consisting of 0.5 M sulfuric acid and 0.2 M sodium chloride solution, in the presence of methyl orange as indicator. The electrogenerated chlorine reac...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The preparation of a number of derivatives of 2H-4,6-dimethyl-3-oxo-2,3-dihydroisothiazolo [5,4-b] pyridine (1) containing 4-methyl(phenyl, heteroaryl)-1-piperazinylalkyl moiety by two routes has been described. Preliminary results of pharmacological screening of compounds synthesized showed antipsychotic activity of ...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The hydrophobic nature of drugs, very important feature in determination of biological activity, is in Hansch's approach characterized by the logarithm of partition coefficient (log P) determined in n-octanol -water system, or calculated from hydrophobic constants pi (Hansch) or f (Rekker). Those as well as other para...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Eight antacid mixtures were stored for 110 days at 25 degrees C, 35 degrees C and 45 degrees C in the form of suspensions in water. Changes in pH were followed, and the structural changes in suspension components were studied by X-ray analysis. It has been stated that formation of hydrotalcite, the product od interact...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Procainamide (PA) often applied in cases of ventricular arrhythmias causes numerous cardiac and extracardiac undesirable symptoms. Its active metabolite, N-acetylprocainamide (NAPA; Acecainide) is known to affect less noxiously the ventriculo-atrial conduction and the intraventricular++ conduction, and it does not imp...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Dependence of stability of Amoxycillin trihydrate (AMOXY. 3H2O) and Amoxycillin-Natrium (AMOXY-Na) upon relative humidity (RH) and temperature was investigated using the iodometric method for the determination of Amoxycillin. The first order rate constants and activation parameters have been determined at controlled m...
journal_title：Acta poloniae pharmaceutica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
